Atlas of Physiology and Pathophysiology

1st.FACULTY OF MEDICINE INSTITUTE OF PATHOPHYSIOLOGY, CHARLES UNIVERSITY, LABORATORY OF BIOCYBERNETICS AND COMPUTER AIDED TEACHING Head of laboratory: doc. MUDr. JIŘÍ KOFRÁNEK, CSc.
  • ♦ Physiological control systems
    • 1. Simple systems
    • 2. Static characteristics
    • 3. Dynamic characteristics
    • 4. Mechanical dynamic system
    • 5. Control loop
    • 6. pCO2 regulation model
    • 7. Metabolic systems – enzymatic system model
    • 8. Transportation delay circuit
    • 9. Two degenerative feedbacks – system circulation model

Info

Currently the Atlas is only available in Czech version.
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Regulation

To demonstrate basic system theory and general control loop topics and its application in physiological control. To introduce human organism as a homeostatic self-regulatory system on internal environment and cell population homeostasis.

Circulation

The circulatory system haemodynamics and regulation. ECG signal genesis and disturbances, heart failure pathogenesis and symptoms.

Coagulation and haemostasis

To understand the processes leading to blood coagulation. Blood vessel walls, blood platelets and plasmatic coagulation systems for blood coagulation. To explain the influence of each section disturbances on haemostasis, haemorrhagic diatesis and hypercoagulation conditions using the interactive models.

Gas transport

Explanation of the integrated importance of respiration, circulation and erythropoesis along with acid-base balance for mitochondrial oxygen delivery a carbon dioxide transfer. Causes and effects of various kinds of hypoxia. The ventilation-perfusion influence on blood gases level, the importance of oxygen level in central venous blood (deep oxygen level according to Siggaard-Andersen)

Acid-base

To grasp the coupled acid-base balance regulation. The interrelations of acid-base, ion and volumic balance. The influences of hypoproteinemia and dilution on haemoconcentration and acid-base balance.

Internal environment

To grasp the interrelated ion, volumic, osmotic and acid-base balance connections. To approach the intercellular and intracellular ways of communication, to acquaint with various receptors and signal pathways. Illustrate the fact, that control disturbances of signal pathways may lead to serious diseases.

The cell signalization

The influence of biological membranes physical properties on the membrane potention genesis.

The kidney

Using interactive multimedia graphics and models explain the function of separate nephron parts kidney as a complex, the influence of diuretics, causes and effects of renal disturbances a insufficiency.

Respiration

The lungs anatomical overview as an ideal gas exchanger. What is the diffusion and what influences its speed in lungs. Lung mechanics, compliances and resistances. Inhaling and exhaling mechanism. The ventilation and perfusion distribution and its effect on blood gases content in arterial blood. Obstructive and restrictive respiration diseases, its distinctions, typical examples. ARDS and its pathogenesis. The respiratory system examinations and its principles.

Muscle

Using interactive multimedia graphics and models explain the function of muscle, the properties of muscle contraction and its molecular basis. The grasp the distinction between the skeletal, cardiac and a smooth muscle.

Physical laws

To grasp or to recall the physical and chemical law, that influence the physiological phenomenons in organism.